Metoprolol chemical structure

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    Metoprolol chemical structure


    Metoprolol tartrate is a selective β1-adrenergic receptor blocker,oral absorption is rapid and complete,it is used for the treatment of hypertension, angina pectoris, myocardial infarction, hypertrophic cardiomyopathy, aortic dissection, cardiac arrhythmia, hyperthyroidism, cardiac neurosis and other diseases. In recent years, it is also used for ther treatment of heart failure, which can reduce mortality. In unstable/non-ST-segment elevation myocardial infarction and acute myocardial infarction control guiding principles developed by American Heart Association , effect of metoprolol tartrateare is clearly recognized. In the past, concerns about β-blocker therapy caused hypotension is too large, and for the consideration that there may be racial differences between Asians in β-blocker use and the West, patients with treatment of β-blockers in China is fewer , the use of β-blockers is in lower dose. Metoprolol tartrate has a weaker membrane stability and it has no intrinsic sympathomimetic activity, and in comparison with similar drugs commonly used in clinical propranolol ,in addition to the advantages of β1-blocker on its pharmacodynamic,it also has its pharmacokinetic kinetics advantages, such as relatively weak first-pass effect compared with propranolol, simple metabolic pathways, most pharmacologically inactive metabolites and the like. Category: toxic substances Toxicity grading: Middle poisoning Acute toxicity: oral -rat LD50: 5500 mg/kg; Oral-Mouse LD50: 1500 mg/kg Flammability and hazard characteristics: It is combustible; fire decomposition produces toxic nitrogen oxide gases Storage Characteristics: Ventilated, low-temperature ,dry storeroom. Extinguishing agent: Water, carbon dioxide, dry powder, sandy soil. White or almost white, crystalline powder or colourless crystals. selective aryloxypropanolamine andrenergic antagonist. Used in the treatment of a variety of cardiovascular disorder. Metoprolol has two common trade names, Lopressor and Toprol XL ( Metoprolol being the generic name ). This drug is widely used for managing chronic but stable angina i.e. when the hearts demand for oxygen exceeds the supply of oxygen reaching the heart. It has proved successful in reducing mortality due to cardiovascular diseases such as MI. The drug works essentially by blocking beta-1 receptors using an adrenergic blocker; this has the effect of slowing down the sinus heart rate. It also reduces the force of the heart muscle contraction and thus oxygen demand. This in turn lowers the cardiac output and there is a decrease in the rennin released from the kidney.

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    Structure, properties, spectra, suppliers and links for Metoprolol, 37350-58-6. The tablets contain 23.75 mg of metoprolol succinate equivalent 25 mg of metoprolol tartrate, USP. Its chemical name is ± 1-isopropylamino-3-p-2-methoxyethyl phenoxy-2-propanol succinate 21 salt. Its structural formula is Metoprolol succinate is a white crystalline powder with a molecular Chemical Structure of Metoprolol Tartrate, CAS No. 392-17-7. Chemical Structure of Metoprolol Tartrate, CAS No. 392-17-7. Chemical Structure of Metoprolol Tartrate, CAS No. 392-17-7.

    Metoprolol is used for a number of conditions, including hypertension, angina, acute myocardial infarction, supraventricular tachycardia, ventricular tachycardia, congestive heart failure, and prevention of migraine headaches. receptors in the heart, metoprolol is also prescribed for off-label use in performance anxiety, social anxiety disorder, and other anxiety disorders. Metoprolol is sold in formulations that can be taken by mouth or given intravenously. Side effects, especially with higher doses, include dizziness, drowsiness, fatigue, diarrhea, unusual dreams, trouble sleeping, depression, and vision problems. Metoprolol may also reduce blood flow to the hands or feet, causing them to feel numb and cold; smoking may worsen this effect. Due to the high penetration across the blood-brain barrier, lipophilic beta blockers such as propranolol and metoprolol are more likely than other less lipophilic beta blockers to cause sleep disturbances such as insomnia and vivid dreams and nightmares. Serious side effects that are advised to be reported immediately include symptoms of bradycardia (resting heart rate slower than 60 beats per minute), persistent symptoms of dizziness, fainting and unusual fatigue, bluish discoloration of the fingers and toes, numbness/tingling/swelling of the hands or feet, sexual dysfunction, erectile dysfunction, hair loss, mental/mood changes, depression, breathing difficulty, cough, dyslipidemia and increased thirst. Metoprolol is a cardioselective β1-adrenergic blocking agent used for acute myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. It may also be used for supraventricular and tachyarrhythmias and prophylaxis for migraine headaches. Metoprolol is structurally similar to bisoprolol, acebutolol and atenolol in that it has two substituents in the para position of the benzene ring. The β1-selectivity of these agents is thought to be due in part to the large substituents in the para position. At low doses, metoprolol selectively blocks cardiac β1-adrenergic receptors with little activity against β2-adrenergic receptors of the lungs and vascular smooth muscle. Unlike propranolol and pindolol, metoprolol does not exhibit membrane-stabilizing or intrinsic sympathomimetic activity. Membrane-stabilizing effects are only observed at doses much higher than those needed for β-adrenergic blocking activity. Metoprolol possesses a single chiral centre and is administered as a racemic mixture.

    Metoprolol chemical structure

    Metoprolol tartrate 56392-17-7 - ChemicalBook, Metoprolol succinate Medidex

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  6. Metoprolol C15H25NO3 CID 4171 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities.

    • Metoprolol C15H25NO3 - PubChem.
    • Chemical Structure of Metoprolol Tartrate, CAS.
    • Chemical structure of metoprolol. Download Scientific Diagram.

    Standard solution and Standard dilutions— Dissolve a suitable quantity of USP Metoprolol Tartrate RS,accurately weighed,in chloroform,and dilute quantitatively and stepwise with chloroform to obtain solutions having known concentrations of 1.0,0.5,0.2,and 0.1mg per mL,respectively. Metoprolol succinate Item № 15429. 1,2 This product is a racemic mixture of enantiomers that differ in their in vivo actions and metabolism. 3 Metoprolol is predominantly metabolized by the cytochrome P450 CYP. Molecular Formula. C 15 H 25 NO 3 • 1/2C 4 H 6 O 4. Formula ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. 23092397

     
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