Metformin use in pregnancy

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    Metformin use in pregnancy


    Metformin improves insulin sensitivity and reduces hepatic glucose output in patients with diabetes. It offers potential benefits for pregnant women with gestational or type 2 diabetes because both conditions are associated with increased insulin resistance. Some cohort data are available and randomised trials are currently in progress to compare metformin with insulin, but strong evidence is not yet available to guide management. There are no long-term follow-up data to provide reassurance about the safety of metformin, given its passage across the placenta, although recent evidence suggests that there is no significant risk of teratogenesis. Limited amounts of metformin are transferred into breast milk, but the risk of neonatal hypoglycaemia is negligible. Oral hypoglycaemic drugs have been viewed with suspicion for many years in the management of women with diabetes during pregnancy or breastfeeding. Pregnant women with type 2 diabetes are often switched to insulin. In order to use Medscape, your browser must be set to accept cookies delivered by the Medscape site. Medscape uses cookies to customize the site based on the information we collect at registration. The cookies contain no personally identifiable information and have no effect once you leave the Medscape site.

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    ABSTRACT. QUESTION. A pregnant patient with polycystic ovary syndrome asked me whether continuing metformin, which she was taking to treat infertility. Use of metformin throughout pregnancy in women with polycystic ovary syndrome PCOS has shown to reduce the rates of early pregnancy loss, preterm labor, and prevention of fetal growth restriction. A 31-year-old woman with PCOS and metabolic syndrome was treated with metformin 500 mg twice daily until the 8th week of her first.

    ABSTRACT QUESTION A pregnant patient with polycystic ovary syndrome asked me whether continuing metformin, which she was taking to treat infertility before her pregnancy, was safe for her fetus. She had heard that metformin is a "drug for diabetes." How safe is it to take metformin during the first trimester of pregnancy and beyond? ANSWER Despite the traditional response that all oral hypoglycemic agents are absolutely contraindicated during pregnancy,1-3 evidence that metformin is probably safe during the first trimester of pregnancy and beyond is accumulating. Results of a recent meta-analysis by the Motherisk Program showed no increase in incidence of major malformations and a potential protective effect in this patient population. QUESTION Une de mes patientes enceintes ayant le syndrome des ovaires polykystiques m'a demandé s'il était sans danger pour son foetus de continuer la metformine qu'elle prenait pour traiter l'infertilité avant sa grossesse. Elle a entendu dire que la metformine était un «médicament contre le diabète». Dans quelle mesure est-ce sécuritaire de prendre de la metformine durant le premier trimestre de la grossesse et au-delà? Metformin is a drug that is often prescribed, off-label, for the treatment of PCOS and for regulating ovulation. It belongs to a class of drugs that improves the cells' response to insulin and regulates blood sugar. An off-label prescription means that the FDA has not approved the use of a drug specifically for that condition. In this case, metformin has been approved for the treatment of diabetes but not for PCOS specifically. Because so many women with PCOS also have insulin resistance and diabetes, it is believed that treating the insulin dysfunction might have an effect on the other hormonal irregularities associated with the condition. While researchers aren’t sure of the exact mechanism, there is some evidence that backs up this theory: some studies have shown that women who take a combination of metformin and clomid (a drug that is used to induce ovulation in anovulatory women) have a better response to the medication regimen than those who take clomid alone. Some women with PCOS, especially those that are insulin resistant, may see more regular periods from taking metformin as well.

    Metformin use in pregnancy

    Metformin During Pregnancy Is It Safe to Take? - Healthline, Effects of metformin use in pregnant patients with polycystic.

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  3. Metformin has been prescribed in pregnancy for over 40 years; for much of this time, use has been limited both in numbers and geographically.

    • Metformin use in pregnancy promises and uncertainties - NCBI - NIH.
    • Metformin Use During Pregnancy - Medscape.
    • Is it safe to use metformin during pregnancy? - Health News.

    Pregnant women are tested for diabetes so they can get treatment. Metformin. Metformin is a medicine that has been used for many years to. Abstract. Metformin has been prescribed in pregnancy for over 40 years; for much of this time, use has been limited both in numbers and geographically, and the evidence base has been confined to observational studies. Abstract Metformin use in pregnancy is increasing worldwide as. Keywords metformin; pregnancy; gestational diabetes; polycystic ovarian.

     
  4. maxandr New Member

    When it comes to diabetes there are many success stories, especially among those who know that diet and exercise play a big part in blood sugar control. Medication is also key to getting your numbers into a healthy range. But if you’re like many people who take something daily for diabetes, you probably wonder if you can ever stop. First, know that it's OK to ask your doctor if you can stop taking meds once you’ve met the blood sugar goals you've both set, says Robert Gabbay, MD, Ph D, chief medical officer of the Joslin Diabetes Center in Boston. The first step: Tell your doctor why you want to stop. The doctor’s looking for specific answers, says endocrinologist Gregg Faiman, MD, of University Hospitals Case Medical Center in Cleveland. Maybe -- if your blood sugar numbers are good and you’re committed to a healthy lifestyle. He wants to know: After that, you and your doctor have to agree about how you’re going to keep your blood sugar under control. You wouldn’t be on the drug if you didn’t need it, Faiman says. “Stopping a medication requires an in-depth discussion. You have to commit to keeping your diabetes under control.” If you take the drug metformin, a common treatment for type 2 diabetes, your doctor could lower it in stages as you lose weight and get fitter, Faiman says. Metformin and PCOS Six Reasons Why it Might Not Be Safe to Take. Pre and Post Contrast Information for Patients Taking Metformin Stopping metformin - The Blood Sugar Diet by Michael Mosley
     
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