Misoprostol is a synthetically derived prostaglandin E1 analog which is originally used to treat gastric ulcers but is now widely used for the termination of unintended pregnancies. It causes uterine contractions and opening of the cervix, therefore, aids in the expulsion of the products of conception inside the uterus. The last dose of the day should be taken at bedtime. Misoprostol (Cytotec) is used for reducing the risk of stomach ulcers in certain patients who take nonsteroidal anti-inflammatory drugs (NSAIDs). It works by reducing the amount of acid released by the stomach and protecting the stomach lining, which helps to reduce the risk of stomach ulcers. Taking Cytotec after meals and at bedtime may decrease the risk of diarrhea. Do no take an antacid that has magnecium in it within 1 hour before or 2 hours after you take Cytotec. If you miss a dose of Cytotec, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Ask your health care provider any questions you may have about how to use Cytotec. Concurrent long-term corticosteroid or anticoagulant therapy. Serious and sometimes fatal infections or bleeding. Mifepristone also known as RU-486 is a synthetically produced antiprogesterone agent which blocks the progesterone hormone during the early stage of pregnancy. Nausea, weakness, fever/chills, vomiting, headache, diarrhea, dizziness; uterine bleeding (may be prolonged or severe), cramping; rare: serious bacterial infections, sepsis (may be fatal). 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