I have been on metformin for about 3 months and at 3 weeks developed severe weakness. What have you and your physician done to counteract the problem? Subsequently I have had to stop working out (aerobic cycling and weight lifting) due to severe pain in my back as a result of the induced weakness. The most common medication used in women with PCOS is the insulin-sensitizer metformin. Research is strongly showing that long-term use of metformin and at high doses (1.5mg or higher daily) can deplete levels of vitamin B12. A deficiency of vitamin B12 can cause permanent neurological and nerve damage as well as mood changes and decreased energy. Here’s what you need to know to avoid a vitamin B12 deficiency if you take metformin. Metformin is the most widely used medication used to lower insulin levels in those with polycystic ovary syndrome. Metformin is a medication that became available in the U. Other names for metformin include glucophage, glucophage XR, glumetza, and fortamet. Metformin lowers blood glucose levels in three ways: Metformin use may affect the absorption of vitamin B12 possibly through alterations in intestinal mobility, increased bacterial overgrowth, or alterations of the vitamin B12-intrinsic factor complex. Metformin can cause a malabsorption in B12 due to digestive changes, which leads to the binding of B12-intrinsic factor complex (intrinsic factor is needed to absorb B12 in the gut) and a reduction of B12 absorption. Xanax 2090 Zoloft drug Prednisone with food Side Effects. Drug information provided by IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. I started taking 1000mg metformin around July and had no issues, but I stopped taking it after about 3 weeks. I had no issues then, but I recently started taking 2000mg of metformin worked my way up and have been having extreme fatigue this time around. I also feel nauseated most days. Metformin can cause vitamin B12 deficiency in some people and this would decrease blood counts leading to fatigue and generally difficulty with problem solving, periperal neuropathy, etc. so the lab work would help identify cause. Is it just being tired after working a long week or not getting enough sleep? Fatigue is excessive tiredness that makes carrying out simple tasks difficult and interferes with one or more life functions. Well imagine having a chronic illness along with the fatigue. Diabetes and fatigue have a strong relationship, and it can make a person’s life very difficult. The following article will discuss the relationship, along with ways to beat and reduce the risk of living with diabetes and fatigue. As it was mentioned above, diabetes fatigue is an extreme tiredness that individuals with diabetes can experience. It is a tiredness that disrupts a person’s life and makes it difficult to function. It is very common, and studies have shown that 85% of those with diabetes experience fatigue. Some signs of fatigue include: Feeling fatigued is definitely a symptom of diabetes. I'm taking Metformin 1000mg BID for my PCOS after a few years of not being on it. I was originally taking 500mg ER BID daily which I had minimal issues with, but my new doctor wanted to put me on 2000 daily this time. Since taking the metformin, I feel like I've been experiencing extreme fatigue. I forget now where I read/heard that women on metformin have low B12 levels. Whilst I can usually sleep until 12 regardless, as I sleep late, I could easily sleep past 2pm now - something I haven't been able to do when not severely depressed. Now b12 is more of an energy/metabolism deal but when I'm tired the muscle fatigue really sets in. I don't know if I should try and not take the metformin for a day and see what happens, or if I should just automatically request a lower dose? If I can keep my energy up the fatigue isn't as bad. I'll get 12-14 hours of sleep, and still need to crawl back to bed to sleep another five. Can definitely tell when I've forgotten to take a dose. I'm starting to feel like only part of a human and it's just devastating. I would ask your endo/primary before going too high with your dosage but you can always start small and build and talk with your provider. I hate watching chores pile up around me and life fly by as I'm in bed because literally just walking to the bathroom feels like marathon. Metformin fatigue Metformin cause extreme fatigue? - PCOS Message Board, Has anyone experienced extreme fatigue with metformin? PCOS - reddit Cialis patentWhere can i buy cialis over the counter at walmart The differential diagnosis for fatigue is very broad and common reasons include an underlying viral infection such as mononucleosis, side effects of medication or drugs, anemia, depression, hypothyroid, pregnancy, and cancer. Frustratingly, the cause of fatigue is sometimes never identified. Metformin side effects fatigue - MedHelp. Metformin and fatigue - MedHelp. New Metformin Warning Mandatory Supplementation with Vitamin B12.. Chrnic fatigue, low energy, difficulty sleping bt deep slep for 7-8 hours whn I sleep, dont feel rested, leg numb more Chrnic fatigue, low energy, difficulty sleping bt deep slep for 7-8 hours whn I sleep, dont feel rested, leg numbness. on metformin 1000mg. wht to do? I am also looking for advice. I have been on Metformin for over a year now and have been going to see my GP every month to let him know that I am suffering from fatigue, wobbly legs, extreme tiredness and other similar symptoms. Metformin together with other medicines to treat diabetes that can cause hypoglycaemia such as sulphonylureas, insulin, meglitinides, there is a risk of hypoglycaemia.