Amoxicillin and penicillin

Discussion in 'Canadian Pharmacy Online' started by NEWMANN, 21-Aug-2019.

  1. pastor Moderator

    Amoxicillin and penicillin


    For years, whenever a healthcare provider asked whether you were allergic to any medications, you might have dutifully noted yes, penicillin, which happens to be the most common drug allergy of all. You might not remember ever having an allergic reaction to penicillin, but that’s what your parents always told you, and they wouldn't steer you wrong. Well, a couple of new studies suggest that unless your symptoms were pretty dramatic, you might not be allergic to penicillin after all. Researchers tested children and adults who'd been labeled as allergic to penicillin but whose symptoms were relatively mild and found that most tolerated the drug just fine. Why should you care whether you or your children are allergic to penicillin? While penicillin is the oldest antibiotic, it and other members of the penicillin family, such as amoxicillin, are still effective first-choice treatments for a wide range of bacterial infections. But once people are labeled as allergic to penicillin--previous studies suggest that 5% to 20% of the population have been deemed allergic to the drug--doctors instead prescribe second-choice, broader-spectrum antibiotics, which, in the case of garden-variety bacterial ear infections, is kind of like swatting a fly with a sledgehammer. Amoxicillin is used in the treatment of a number of infections, including acute otitis media, streptococcal pharyngitis, pneumonia, skin infections, urinary tract infections, Salmonella infections, Lyme disease, and chlamydia infections. Children with acute otitis media who are younger than 6 months of age are generally treated with amoxicillin or other antibiotic. Although most children with acute otitis media who are older than two years old do not benefit from treatment with amoxicillin or other antibiotic, such treatment may be helpful in children younger than two years old with acute otitis media that is bilateral or accompanied by ear drainage. In the past, amoxicillin was dosed three times daily when used to treat acute otitis media, which resulted in missed doses in routine ambulatory practice. There is now evidence that two times daily dosing or once daily dosing has similar effectiveness. Amoxicillin is recommended as the preferred first-line treatment for community-acquired pneumonia in adults by the National Institute for Health and Care Excellence, either alone (mild to moderate severity disease) or in combination with a macrolide. It is effective as one part of a multi-drug regimen for treatment of stomach infections of Helicobacter pylori.

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    Penicillin is a group of antibiotics that are commonly used to treat different types of gram positive and gram negative bacterial infections. In their structure, beta lactam ring is located due to this reason these drugs are also called as beta lactam antibiotics. Amoxicillin vs Penicillin comparison. Penicillin and amoxicillin are antibiotics, compounds that disrupt and destroy bacteria. Penicillin is the precursor to. Amoxicillin is in the penicillin class of antibiotics. All penicillins are distinguished by the presence of a beta-lactam ring, and are known to kill bacteria by inhibiting synthesis production of bacterial cell walls.

    Most people who think they are allergic to penicillin in fact are not, researchers said Friday. It’s something doctors have suspected for a long time, but the researchers say they were surprised by just how many people weren’t allergic to the antibiotic: it was 94 percent of them. Thanai Pongdee, an allergist at the Mayo Clinic in Jacksonville, Florida and colleagues tested 384 people who said they were allergic to penicillin. Tests showed 94 percent of them were in fact, not allergic.“These patients were scheduled to undergo orthopedic, general surgery, neurosurgery--any type of surgery you can think of,” Pongdee told NBC News. “We probably expected a little over half of people would not be allergic based on the time frame when they were initially determined to be allergic, but it ended up being a much higher proportion than that.”It’s good news for the patients, who can get cheaper, more generic penicillin-based drugs such as amoxicillin or related drugs called cephalosporins. These antibiotics generally cause fewer side-effects than other antibiotics, and they allow doctors to save the other drugs for penicillin-resistant infections.“There are two issues: these patients are put on other antibiotics which be less effective and potentially have more side-effects,” said Dr. James Sublett, a family allergist in Louisville, Kentucky who is incoming president of the American College of Allergy, Asthma and Immunology (ACAAI).“The other is cost. A very commonly used substitute, for example Levaquin, is seven to eight times more expensive for a 10-day course than a similar course of generic Augmentin, a penicillin drug.”“A patient will say, ‘My mom told me when I was 3 years old (that) I had a reaction to penicillin. Patients from 18 to 75 years of age with no significant associated comorbidity and with symptoms of lower respiratory tract infection and radiological confirmation of CAP were randomized to receive either penicillin V 1.6 million units, or amoxicillin 1000 mg three times per day for 10 days. The main outcome was clinical cure at 14 days, and the primary hypothesis was that penicillin V would be non-inferior to amoxicillin with regard to this outcome, with a margin of 15% for the difference in proportions. A total of 43 subjects (amoxicillin: 28; penicillin: 15) were randomized. Clinical cure was observed in 10 (90.9%) patients assigned to penicillin and in 25 (100%) patients assigned to amoxicillin with a difference of −9.1% (95% CI, −41.3% to 6.4%; There was a trend favoring high-dose amoxicillin versus high-dose penicillin in adults with uncomplicated CAP. The main limitation of this trial was the low statistical power due to the low number of patients included. Se reclutaron pacientes de 18 a 75 años de edad sin comorbilidad asociada importante, con síntomas de infección respiratoria inferior y confirmación radiológica de neumonía, que fueron asignados aleatoriamente a 1,6 M unidades de penicilina V o amoxicilina 1.000 mg, 3 veces al día, durante 10 días. La variable de resultado principal fue curación clínica a los 14 días y se planteó la hipótesis de que penicilina no era inferior a amoxicilina con un margen de 15% para la diferencia de proporciones. Se aleatorizaron 43 personas (amoxicilina: 28; penicilina: 15). Se observó curación clínica en 10 pacientes asignados a penicilina (90,9%) y en 25 asignados a amoxicilina (100%), observándose una diferencia de –9,1% (IC 95%: –41,3 a 6,4%; p = 0,951) para no inferioridad.

    Amoxicillin and penicillin

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  7. Nov 7, 2014. Most people who think they are allergic to penicillin in fact are not. more generic penicillin-based drugs such as amoxicillin or related drugs.

    • Allergic to Penicillin? You're Probably Not - NBC News.
    • Amoxicillin - Answers on HealthTap.
    • What is the difference between Penicillin and Amoxicillin? - Quora.

    WebMD provides information about interactions between Amoxicillin Oral and penicillins-tetracyclines. Feb 2, 2018. Understand the importance of an accurate diagnosis for penicillin allergy. Amoxicillin; Ampicillin; Dicloxacillin; Nafcillin; Oxacillin; Penicillin G. With regard to medications, but hearing “penicillin allergy” by a health care provider is likely to raise a red flag. Eliminating the use of penicillin, amoxicillin.

     
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