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    Generic Viagra is a prescription medicine which is generic counterpart of the brand Viagra used for medical management of male impotence or erectile Dysfunction. Erectile Dysfunction (ED) is a common male sexual brokenness issue which is described as a consistent incapacity of a man to attain erection even when they are significantly aroused. It negatively affects the sexual life as well as the self-esteem and confidence of the sufferer. Moreover, ED may be a very strong indication of many serious organic physiological problems like heart disease, diabetes etc. Generic Viagra is a drug which can deal with ED and avert related difficulties. Regardless of the cause of ED, Generic Viagra can assist ED affected men stay free from its adversities. There are numerous causes involve behind ED, but researchers opine that the main reason behind ED is insufficient flow of blood to the penile region. How to Talk to Your Doctor Given that ED is such a common problem, don't be too daunted about talking to your doctor about it. However, don't expect them to throw you a bunch of free samples right away. First, they are going to want to make sure your erectile issues require medication. They will likely ask about your diet, weight, stress-levels, and sleep. "Making sure the dysfunction is from a medical problem and not necessarily related to anxiety or a psychogenic cause is also important to tease out before to running to give them medicine," says Dr. Benjamin Breyer, Chief of Urology at San Francisco General Hospital. Medical history can also be an important factor, especially for men who have had surgery or radiation that could affect functioning.

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    The success of azoles and polyenes in addressing a high medical need has been significant, despite their mutually exclusive limitations. Both drug classes operate by inhibiting sterol function in the fungal cell membrane, to exert an antifungal effect (see However, azoles indirectly target ergosterol function via fungal-specific inhibition of 14-sterol demethylase, to block the synthesis of functional ergosterol from nonfunctional lanosterol. No significant effect on human/mammalian cholesterol biosynthesis is achieved in vivo as a result of this activity, which underpins the mechanistic safety of azoles and As has been pointed out already, it will be important to have an azole moiety in our new antifungal; however, it should not have the 1:3-dioxolane ring system present in the structures of 23, 24, and 25, because it is expected that such a ring system might induce instability of the drug under the acidic conditions in the stomach. Thus, we wished to explore whether other oxygen-containing heterocycles represented by 26, 27, 28, 29, and 30 will possess activities of interest. We have synthesized all these novel structures with appropriate R groups in the racemic form, and determined their activities, and the results are as follows: 26, 27, and 28 were more active than 23 and 24, and, among these compounds, 27 was the most active. In this chapter we focus on the synthesis of this class of compounds that led to the discovery of posaconazole (21). In our initial studies the importance of the aromatic spacer group –OR, and the presence of an azole moiety for its broad-spectrum activity, potency, and oral bioavailability, became apparent. FileFluconazole - Wikimedia Commons Effects of three cytochrome P450 inhibitors, ketoconazole. DB00196 Fluconazole - Fluconazole - DrugBank
     
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