Erythromycin alcoholic solution contains the active ingredient erythromycin, which is a type of medicine known as a macrolide antibiotic. It interferes with bacterial protein synthesis by binding to the 50S subunit of ribosomes of sensitive organisms. Erythromycin solution is applied to the skin to treat acne. The erythromycin works by attacking the bacteria associated with acne, Propionibacterium acnes. This is a common type of bacteria that feeds on sebum produced by the sebaceous glands in the skin. Although the mechanism of action of Erythromycin in reducing inflammatory lesions of acne vulgaris has not been conclusively shown, it is presumably due to its antibiotic action on sensitive bacteria, and in reducing follicular porphyrin fluorescence and free fatty acid levels of skin lipids. Erythromycin prevens these bacteria from producing proteins that are essential to them. Without these proteins the bacteria cannot grow, replicate and increase in numbers. Use erythromycin solution twice daily, in the morning and the evening. Apply it to all of the affected area of skin, not just to individual spots. You may need to use the solution for 10-12 weeks before you notice the full benefit. Most people with acne are aged between 12 and 25 years, but some older and younger people are affected too. Small sebaceous glands lie just under your skin surface and make an oil (sebum) that keeps your skin supple and smooth. Tiny pores on your skin allow the sebum to come on to the surface of your skin. In acne, some of these pores become blocked, causing inflamed spots. There are also other skin preparations available which contain erythromycin and are prescribed for acne. Antibiotics, like erythromycin, work by killing germs (bacteria) that can contribute to acne. Erythromycin usually works well to clear acne spots which are inflamed and any surrounding skin inflammation. These gels/solutions combine erythromycin with a topical retinoid agent. 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Find patient medical information for Erythromycin Topical on WebMD including its uses, side effects and safety, interactions, pictures. This medication is used to treat acne. Use this medication regularly in order to get the most benefit from it.