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Equine metabolic syndrome (EMS), is an endocrinopathy affecting horses and ponies. It is of primary concern due to its link to obesity, insulin resistance, and subsequent laminitis. There are some similarities in clinical signs between EMS and pituitary pars intermedia dysfunction, also known as PPID or Cushing's disease, and some equines may develop both, but they are not the same condition, having different causes and different treatment. The cells of adipose (fat) tissue synthesizes hormones known as adipokines. In humans, dysfunction of adipose tissue, even in cases without obesity, has been associated with the development of insulin resistance, hypertension, systemic inflammation, and increased risk of blood clots (thrombosis). The inflammation produced by these hormones are thought to inflame adipose tissue, leading to the production of more adipokines and perpetuation of the cycle, and a constant low-level, pro-inflammatory state. Although it is suspected that a similar mechanism occurs in horses, further research is needed. Упаковка должна быть такой же, как упаковка этого товара в розничных магазинах, за исключением тех случаев, когда товар является изделием ручной работы или был упакован производителем в упаковку не для розничной продажи, например в коробку без маркировки или в пластиковый пакет. объявление продавца о товаре для получения полной информации. Показать все определения состояния — открываются в новом окне или вкладке * Расчетный срок доставки- открывается в новом окне или вкладке включает в себя время обработки заказа продавцом, почтовый индекс отправителя и получателя, время получения заказа службой доставки, зависит от выбранной службы доставки и срока получения обработанного платежа- открывается в новом окне или вкладке. Время доставки может варьироваться, особенно в пиковые периоды. Установите максимальную цену, которую вы готовы заплатить за этот товар. 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However, the oral bioavailability of metformin in horses is reported as only 7.1. Horse chestnut oral increases effects of metformin oral by pharmacodynamic synergism. Clinical Drug Interactions Source Medscape from WebMD. © 1994-2018 WebMD, LLC.